apalutamide will reduce the level or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medications that happen to be CYP3A4 substrates may end up in decreased exposure to these medications.Codeine is from a group of medicines re